Have you got a headache, muscle pain, or cramps? No worry, as over-the-counter (OTC) pain relievers can help you. Unlike prescription opioids, OTC painkillers aren’t addictive and won’t make you feel groggy, dizzy, or constipated. They’re also affordable and easy to find. You can even go for generic versions of drugs that are as effective as brand names but are cheaper.
We checked reviews from over 3,500 people to see how happy they were with OTC pain relievers. The result was that most of them found OTC painkillers to be worth trying. At least 70% of the reviewers said each pain relief medication worked well for them.
Below are the scores to indicate how good these OTC pain relievers are, according to user reviews. The scores are based on their effectiveness and any side effects they may have. We’ll also provide essential details about each pain relief medication.
In this blog, you’ll learn:
What Are OTC Pain Relievers?
OTC pain relievers to manage mild to moderate pain can be purchased without a prescription. They are available in different forms, such as tablets, capsules, liquids, creams, and patches, and can be found in the pharmacy section of drug stores or supermarkets.
There are various OTC pain relievers, each with unique properties and uses. Nonsteroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen and Naproxen are most commonly used to reduce inflammation and relieve pain associated with arthritis, menstrual cramps, and headaches. On the other hand, acetaminophen is used to reduce pain and fever and is less likely to cause stomach problems than NSAIDs.
Topical pain relievers like creams, Lidocaine patches, or Capsaicin can be directly applied to the skin to relieve muscle and joint pain. While aspirin primarily reduces fever and inflammation, it can also relieve pain. Remember to follow the instructions on the label and consult a healthcare provider if unsure which medication is best for you.
7 Best Over-the-Counter Pain Relievers
According to drugs.com’s user’s review and rating, We select the 7 best over-the-counter pain relievers: acetaminophen, aspirin, Ibuprofen, naproxen, Diclofenac, Lidocaine, and Capsaicin topical. These most common medications effectively treat the pain associated with headaches, muscle aches, menstrual cramps, arthritis, and more. However, following the recommended dosage and considering potential side effects is essential.
| Drug Name | Rating | Reviews | |
|---|---|---|---|
| ibuprofen | 7.7 | 53 reviews | |
| diclofenac | 6.9 | 257 reviews | |
| aspirin | 6.7 | 12 reviews | |
| naproxen | 6.2 | 105 reviews | |
| acetaminophen | 6.0 | 59 reviews | |
| capsaicin | 4.8 | 64 reviews | |
| lidocaine | 4.6 | 140 reviews |
Acetaminophen – Users Rating: 8.1/10
Acetaminophen, or paracetamol, is a common over-the-counter pain reliever and fever reducer sold under various brand names, such as Tylenol and Panadol. It is not an NSAID like Ibuprofen or Diclofenac but is also approved to treat pain and reduce fever. Acetaminophen works by blocking specific chemicals in the brain that cause pain and fever.
According to Drugs.com’s User Reviews, Acetaminophen has an average rating of 8.1 out of 10, indicating that most users found it effective in relieving pain. However, some users reported experiencing side effects such as nausea, dizziness, and headache.
The maximum recommended daily dose of acetaminophen for adults is 4,000 milligrams (mg), which is equivalent to eight extra-strength tablets (500 mg each) or 12 regular-strength pills (325 mg each) per day. It is essential to follow the suggested dose to avoid potential liver damage or other serious side effects, especially if you have underlying medical conditions or are taking other medications.
While acetaminophen is generally safe and effective when used as directed, it can cause liver damage or other serious side effects if taken excessively or for prolonged periods. It is also essential to avoid alcohol while taking acetaminophen, as it can increase the risk of liver damage.
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Ibuprofen – Users Rating: 7.5/10
Ibuprofen is part of a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs), which work by reducing inflammation in the body. It is available over-the-counter under various brand names such as Advil, Motrin, and Nurofen and in prescription-strength formulations.
Ibuprofen is approved to treat various conditions that cause pain and inflammation, including headaches, menstrual cramps, dental pain, muscle aches, and arthritis. It is available in multiple forms, such as tablets, capsules, and liquids, and the dosage may vary depending on the condition being treated and the age of the person taking it.
According to Drugs.com’s User Reviews, Ibuprofen has an average rating of 7.5 out of 10. Most people who have used Ibuprofen to treat pain found it effective in providing relief. However, it is essential to note that Ibuprofen can cause side effects like all medications. Common side effects of Ibuprofen include stomach upset, heartburn, nausea, vomiting, and dizziness.
Following the recommended dose of Ibuprofen is essential to avoid potential side effects. The maximum recommended daily dose for adults is 1200 mg, divided into three or four doses. However, the dose may vary depending on the individual’s medical history, age, and other factors.
Diclofenac – Users Rating: 7.2/10
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) sold under various brand names, such as Voltaren, Cataflam, and Arthrotec. It is approved to treat pain and inflammation associated with arthritis, menstrual cramps, and migraine headaches.
According to Drugs.com’s User Reviews, Diclofenac has an average rating of 7.2 out of 10, indicating that most users found it effective in relieving pain. However, some users reported experiencing side effects such as stomach upset, headaches, and dizziness.
Following the recommended dose of Diclofenac is essential to avoid potential side effects. The maximum recommended daily dose for adults is 150 mg, divided into two or three doses.
Diclofenac works by blocking the production of certain chemicals in the body that cause inflammation and pain. It is available in various forms, such as tablets, capsules, and gels, and the dosage may vary depending on the condition being treated and the age of the person taking it.
Like all NSAIDs, Diclofenac can cause side effects such as stomach upset, heartburn, and dizziness. It can also increase the risk of severe side effects such as bleeding and stomach ulcers, especially in people who take it for long periods or at high doses.
Aspirin – Users Rating: 7.7/10
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) sold under various brand names such as Bayer, Bufferin, and Ecotrin. It is approved to treat mild to moderate pain, fever, and inflammation and reduce the risk of heart attacks and strokes in specific populations.
According to Drugs.com’s User Reviews, aspirin has an average rating of 7.7 out of 10, indicating that most users found it effective in relieving pain. However, some users reported experiencing side effects such as stomach upset, ear ringing, and bruising.
The maximum recommended dose of aspirin varies depending on the condition being treated and the age of the person taking it. For pain relief, the usual dose for adults is 325 to 650 milligrams every 4 to 6 hours, up to a maximum of 4 grams per day. However, following the recommended dose and not exceeding the maximum amount is essential, as aspirin can cause serious side effects such as stomach bleeding and kidney damage at higher doses.
Aspirin works by blocking the production of certain chemicals in the body that cause pain, fever, and inflammation. It is available in various forms, such as tablets, capsules, and chewable tablets, and is often combined with other pain relievers or medications.
Naproxen – Users Rating: 7.9/10
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) sold under various brands, such as Aleve and Naprosyn. It is approved to treat pain and inflammation associated with arthritis, menstrual cramps, and gout.
According to Drugs.com’s User Reviews, Naproxen has an average rating of 7.9 out of 10, indicating that most users found it effective in relieving pain. However, some users reported experiencing side effects such as stomach upset, headaches, and dizziness.
It is essential to follow the recommended dose of Naproxen to avoid potential side effects. The maximum recommended daily dose for adults is 1100 mg, which can be taken in divided doses throughout the day.
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Naproxen works by stopping the production of certain chemicals in the body that cause inflammation and pain. It is available in various forms, such as tablets and liquid, and the dosage may vary depending on the condition being treated and the age of the person taking it.
Like all NSAIDs, Naproxen can cause side effects such as stomach upset, heartburn, and dizziness. It can also increase the risk of severe side effects such as bleeding and stomach ulcers, especially in people who take it for long periods or at high doses.
Lidocaine – Users Rating: 8.3/10
Lidocaine is a local anesthetic available under various brand names such as Xylocaine, Lidoderm, and Solarcaine. It belongs to the class of drugs known as amide-type local anesthetics. It is approved to treat pain and discomfort associated with various conditions, including minor burns, insect bites, and dental procedures.
According to Drugs.com’s User Reviews, Lidocaine has an average rating of 8.3 out of 10, indicating that most users found it effective in relieving pain. Lidocaine is often used topically as a gel or cream but can also be administered as an injection or a patch.
The maximum recommended dose of Lidocaine depends on the form of the medication being used and the condition being treated. For topical use, the recommended dose should not exceed 4.5 grams per day in adults. The recommended maximum dose for injectable Lidocaine is 4.5 milligrams per kilogram of body weight.
While Lidocaine is generally considered safe when used as directed, it can cause side effects such as skin irritation, dizziness, and headaches. Following the recommended dose and seeking medical attention if you experience any severe or persistent side effects is necessary.
Capsaicin – Users Rating: 6.9/10
Capsaicin is a topical medication derived from chili peppers sold under various brand names, such as Zostrix, Capzasin-P, and Salonpas-Hot. It belongs to a class of drugs known as topical analgesics and is approved to treat pain associated with conditions such as arthritis, neuropathy, and muscle strains.
According to Drugs.com’s User Reviews, Capsaicin has an average rating of 6.9 out of 10, indicating that most users found it effective in relieving pain. However, some users reported experiencing a burning sensation, redness, and skin irritation at the application site.
The recommended dose of Capsaicin may vary depending on the brand and strength of the medication. It is essential to follow the instructions provided by the healthcare provider or the product label. Generally, it is recommended to apply a small amount of the medication to the affected area up to four times daily. It is essential to avoid using Capsaicin to break skin or mucous membranes as it can cause further irritation.
Capsaicin works by depleting a neurotransmitter called Substance P, which plays a role in transmitting pain signals to the brain. It is available in various forms, such as creams, gels, and patches, and the dosage may vary depending on the condition being treated and the age of the person using it. Capsaicin can cause side effects like skin irritation, redness, and burning sensation like all medications.
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Final Words From AzDrug
Over-the-counter (OTC) pain relievers like acetaminophen, aspirin, and Ibuprofen can effectively treat mild to moderate pain associated with various conditions, including headaches, menstrual cramps, muscle strains, and arthritis. These medications are easily accessible and more affordable than prescription painkillers.
However, using these medications cautiously and following the recommended dosages is essential. Overusing or misusing OTC pain relievers can cause adverse effects, such as liver or kidney damage, stomach ulcers, and an increased risk of heart attack or stroke.
It is also important to note that not all OTC pain relievers suit everyone. People with certain medical conditions or taking other medications may need to avoid inevitable pain relievers or use them under medical supervision.
To ensure the safe and effective use of OTC pain relievers, it is recommended to consult with a healthcare provider before using them, especially if you have underlying medical conditions. They can help determine your condition’s most appropriate medication and dosage and guide you on potential risks and side effects.
What is the No 1 for pain relief?
There is no universal "No 1" pain reliever, as individual effectiveness varies. Common options include acetaminophen, ibuprofen, and aspirin.
What are the top 3 pain relievers?
The top three pain relievers include acetaminophen, ibuprofen, and aspirin, each with different mechanisms and considerations.
What is the best pain reliever that is not a narcotic?
Non-narcotic pain relievers include acetaminophen, ibuprofen, and naproxen, often recommended for mild to moderate pain.
What is the safest pain reliever for seniors?
Acetaminophen is generally considered safer for seniors when used as directed, with careful monitoring of dosage to avoid liver issues.
What is the strongest anti-inflammatory drug?
Prescription nonsteroidal anti-inflammatory drugs (NSAIDs) like diclofenac or celecoxib are among the strongest anti-inflammatories.
What are the strongest over-the-counter muscle pain relievers?
Over-the-counter muscle pain relievers include NSAIDs like ibuprofen and naproxen, as well as topical analgesics such as diclofenac gel.
What are the strongest over-the-counter painkillers for arthritis?
Over-the-counter painkillers for arthritis often include NSAIDs like ibuprofen or naproxen. Topical analgesics and joint supplements may also be beneficial.